Tophaceous joint disease strongly predicts hand function in patients with gout

Tophaceous joint disease strongly predicts hand function in patients with gout.

OBJECTIVES The functional impact of gout is poorly understood. The aim of this study was to determine predictors of hand function in gout. METHODS Twenty unselected patients with gout were recruited from rheumatology clinics. No patient had an acute gout flare at assessment. Participants were assessed for clinical characteristics of gout, including the site and number of tophi. Hand function ...

Chronic tophaceous gout in patients with psoriasis*

Psoriasis is a chronic inflammatory disease of multifactorial etiology influenced by genetic, immunological, and environmental factors. We report the case of a patient with psoriasis for more than 25 years who developed hyperuricemia and chronic tophaceous gout with unusual appearance. In psoriasis, hyperuricemia may occur by increased epidermal cell turnover, which accelerates purine metabolis...

Multiple Tophaceous Gout of Hand with Extensor Tendon Rupture

A 45-year-old man presented with painless subcutaneous masses bilaterally on his hands and loss of motion or contracture of the fingers. Initially, drug therapy to reduce the serum uric acid was administered and was expected to reduce the tophi. However, during observation at the clinic, spontaneous rupture of an extensor tendon occurred, and surgical repair of the tendon and resection of the m...

Profound Urate-Lowering May Reduce Joint Damage in Tophaceous Gout

Sickle Cell Disease Presenting with Chronic Tophaceous Gout.

Fig. 6: Cytosmear – clumps of needle shaped crystals topic. I t is hypothesised that this association is rare due to circulatory impairment resulting from congestion and thrombosis of small vessels, in synovia.4 This prevents white blood cells from responding to chemotactic stimulus of uric acid crystals. Activity of the polymorphs is also reduced by anaerobic condition present in SCD. Another ...